Concepedia

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

Daniel Nedelcu, Jing Liu, Yangqing Xu, Cindy Y. Jao, Adrian Salic

Nature Chemical Biology · 2013 · 212 citations · 29 references

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29

Vertebrate Smoothened functions at the primary cilium

Kevin C. Corbit, Pia Aanstad, Veena Singla et al. · Nature · 2005 · 1.5K citations

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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

James Chen, Jussi Taipale, Michael K. Cooper et al. · Genes & Development · 2002 · 1.5K citations · Full text

, , +13

Patched1 Regulates Hedgehog Signaling at the Primary Cilium

Rajat Rohatgi, Ljiljana Milenković, Matthew P. Scott · Science · 2007 · 1.5K citations

, , +17

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Jussi Taipale, James Chen, Michael K. Cooper et al. · Nature · 2000 · 1.3K citations

, , +9

Small molecule modulation of Smoothened activity

James Chen, Jussi Taipale, Keith E. Young et al. · Proceedings of the National Academy of Sciences · 2002 · 996 citations

, , +13