Concepedia

Smoothened Activation

Smoothened Activation is a molecular signaling event within the Hedgehog pathway in which the transmembrane protein Smoothened transitions from an inactive to an active conformation upon relief of inhibitory regulation by Patched, thereby initiating downstream signal transduction.

173

Publications

16.8K

Citations

1.1K

Authors

331

Institutions

Publications per year

2017–2026

53

Parents

Publications

173

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

Marcel Kool, David Jones, Natalie Jäger et al. · Cancer Cell · 2014 · 779 citations · Full text

, , +14

The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal

Joy Alcedo, Marina Ayzenzon, Tonia Von Ohlen et al. · Cell · 1996 · 601 citations · Full text

, , +13

Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened

Natalie Denef, Dagmar Neubüser, Lídia Pérez et al. · Cell · 2000 · 531 citations · Full text

, , +10

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Maria Frank-Kamenetsky, Xiaoyan M. Zhang, Steve Bottega et al. · Journal of Biology · 2002 · 489 citations · Full text

, , +15

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

Marcel van den Heuvel, Philip W. Ingham · Nature · 1996 · 477 citations

, , +11

1–5 of 173

Authors

1.1K

  1. RR
    Rajat Rohatgi

    Stanford University, United States

    9 publications · 1.5K citations

    9

    h-index

  2. JJ
    Jin Jiang

    The University of Texas Southwestern Medical Center, United States

    9 publications · 963 citations

    9

    h-index

  3. PA
    Philip A. Beachy

    Howard Hughes Medical Institute, United States

    8 publications · 1.3K citations

    8

    h-index

  4. BR
    Benjamin R. Myers

    Howard Hughes Medical Institute, United States

    7 publications · 936 citations

    7

    h-index

  5. PW
    Philip W. Ingham

    University of Sheffield, United Kingdom

    7 publications · 1.2K citations

    7

    h-index

1–5 of 1.1K

Institutions

331

  1. Stanford University

    Stanford, United States

    23 h-index

    82 publications

    13.1K citations

  2. The University of Texas Southwestern Medical Center

    Dallas, United States

    13 h-index

    61 publications

    5.7K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    13 h-index

    56 publications

    10.1K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    11 h-index

    54 publications

    3.3K citations

  5. University of California, San Francisco

    San Francisco, United States

    10 h-index

    38 publications

    4.3K citations

  6. Harvard University

    Cambridge, United States

    9 h-index

    50 publications

    8K citations

  7. Duke Medical Center

    Durham, United States

    7 h-index

    28 publications

    5K citations

  8. Duke University Hospital

    Durham, United States

    7 h-index

    27 publications

    4.9K citations

1–8 of 331

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 10 publications · 1.2K citations

    10

    h-index

  2. Journal of Biological Chemistry

    JBC · 7 publications · 305 citations

    8

    h-index

  3. Development

    8 publications · 588 citations

    8

    h-index

  4. PLoS ONE

    6 publications · 228 citations

    7

    h-index

  5. Nature

    6 publications · 1.9K citations

    6

    h-index

1–5