Concepedia

Cerebrospinal Fluid Amyloid-β (Aβ) as an Effect Biomarker for Brain Aβ Lowering Verified by Quantitative Preclinical Analyses

Yasong Lu, David Riddell, Éva Hajós‐Korcsok, Kelly R. Bales, Kathleen M. Wood, Charles E. Nolan, Ashley Robshaw, Liming Zhang, Louis Leung, Stacey L. Becker,

Journal of Pharmacology and Experimental Therapeutics · 2012 · 36 citations · 16 references

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16

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen et al. · Nature Medicine · 1996 · 2.6K citations

, , +16

Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease

Kwasi G. Mawuenyega, Wendy Sigurdson, Vitaliy Ovod et al. · Science · 2010 · 2.1K citations · Full text

, , +13

Human amyloid-β synthesis and clearance rates as measured in cerebrospinal fluid in vivo

Randall J. Bateman, Ling Y. Munsell, John C. Morris et al. · Nature Medicine · 2006 · 590 citations · Full text

, , +14

Robust Central Reduction of Amyloid-β in Humans with an Orally Available, Non-Peptidic β-Secretase Inhibitor

Patrick C. May, Robert A. Dean, Stephen L. Lowe et al. · Journal of Neuroscience · 2011 · 369 citations · Full text

, , +16

A γ‐secretase inhibitor decreases amyloid‐β production in the central nervous system

Randall J. Bateman, Eric Siemers, Kwasi G. Mawuenyega et al. · Annals of Neurology · 2009 · 323 citations · Full text

, , +12