Louis Leung

Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition

Jean‐Baptiste Telliez, Martin E. Dowty, Lu Wang et al. · ACS Chemical Biology · 2016 · 196 citations · Full text

Life Sciences, Immunology, Medicinal Chemistry +17

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2<i>S</i>,5<i>R</i>)-5-((7<i>H</i>-Pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans

Atli Thorarensen, Martin E. Dowty, Mary Ellen Banker et al. · Journal of Medicinal Chemistry · 2017 · 165 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Structure-Based Optimization of Protein Tyrosine Phosphatase 1B Inhibitors:  From the Active Site to the Second Phosphotyrosine Binding Site

Douglas Wilson, Zhao‐Kui Wan, Weixin Xu et al. · Journal of Medicinal Chemistry · 2007 · 164 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic<i>in vitro</i>Assays

Falgun Shah, Louis Leung, Hugh A. Barton et al. · Toxicological Sciences · 2015 · 144 citations · Full text

Pharmacy, Pharmacology, Toxicology +17

Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine

Louis Leung, Thomas A. Baillie · Journal of Medicinal Chemistry · 1986 · 133 citations

Medicine, Anesthesiology, Pharmacology +15