David Riddell

ApoE Promotes the Proteolytic Degradation of Aβ

Qingguang Jiang, C.Y. Daniel Lee, Shweta Mandrekar et al. · Neuron · 2008 · 867 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

Antonia F. Stepan, Chakrapani Subramanyam, Ivan Efremov et al. · Journal of Medicinal Chemistry · 2012 · 446 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels

David Riddell, Hua Zhou, Kevin Atchison et al. · Journal of Neuroscience · 2008 · 347 citations · Full text

Life Sciences, Genetics, Neuroscience +16

Compartmentalization of β-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

David Riddell, Gary Christie, Ishrut Hussain et al. · Current Biology · 2001 · 302 citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease

David Riddell, Hua Zhou, Thomas A. Comery et al. · Molecular and Cellular Neuroscience · 2007 · 248 citations

Life Sciences, Neuroscience, Pharmacology +16