Concepedia

Biomarker Modeling

Biomarker Modeling is a quantitative pharmacometric modeling approach that characterizes and predicts the temporal behavior of biomarkers located on the causal pathway between drug exposure and clinical outcomes, thereby linking dose, pharmacokinetics, and pharmacodynamic responses within pharmacokinetic-pharmacodynamic analyses.

802

Publications

40.2K

Citations

5.3K

Authors

1.7K

Institutions

Publications per year

2017–2026

385

Parents

Children

Publications

802

Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers

Michael Pencina, Ralph B. D’Agostino, Ewout W. Steyerberg · Statistics in Medicine · 2010 · 2.4K citations · Full text

, , +17

Youden Index and Optimal Cut‐Point Estimated from Observations Affected by a Lower Limit of Detection

Marcus D. Ruopp, Neil J. Perkins, Brian W. Whitcomb et al. · Biometrical Journal · 2008 · 1.3K citations · Full text

, , +14

Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia

David T. Teachey, Simon F. Lacey, Pamela A. Shaw et al. · Cancer Discovery · 2016 · 1.1K citations · Full text

, , +17

Translational biomarker discovery in clinical metabolomics: an introductory tutorial

Jianguo Xia, David Broadhurst, Michael Wilson et al. · Metabolomics · 2012 · 957 citations · Full text

, , +17

A novel “Integrated Biomarker Response” calculation based on reference deviation concept

Wilfried Sánchez, Thierry Burgeot, Jean‐Marc Porcher · Environmental Science and Pollution Research · 2012 · 763 citations · Full text

, , +6

1–5 of 802

Authors

5.3K

  1. EF
    Enrique F. Schisterman

    Eunice Kennedy Shriver National Institute of Child Health and Human Development, United States

    11 publications · 2.2K citations

    11

    h-index

  2. LE
    Lena E. Friberg

    Uppsala University, Sweden

    8 publications · 169 citations

    8

    h-index

  3. ZF
    Ziding Feng

    Fred Hutch Cancer Center, United States

    8 publications · 418 citations

    8

    h-index

  4. YH
    Ying Huang

    Fred Hutch Cancer Center, United States

    8 publications · 278 citations

    8

    h-index

  5. MS
    Margaret S. Pepe

    Fred Hutch Cancer Center, United States

    7 publications · 590 citations

    7

    h-index

1–5 of 5.3K

Institutions

1.7K

  1. Harvard University

    Cambridge, United States

    25 h-index

    82 publications

    3.9K citations

  2. Inserm

    Paris, France

    22 h-index

    148 publications

    6K citations

  3. University of Washington

    Seattle, United States

    21 h-index

    74 publications

    3.7K citations

  4. Fred Hutch Cancer Center

    Seattle, United States

    21 h-index

    85 publications

    3.4K citations

  5. Pfizer (United States)

    New York, United States

    17 h-index

    49 publications

    1.7K citations

  6. University of Michigan

    Ann Arbor, United States

    17 h-index

    59 publications

    2.1K citations

  7. Johns Hopkins University

    Baltimore, United States

    17 h-index

    40 publications

    2K citations

  8. Imperial College London

    London, United Kingdom

    16 h-index

    58 publications

    2.5K citations

1–8 of 1.7K

Venues

  1. Statistics in Medicine

    41 publications · 4.5K citations

    21

    h-index

  2. Biometrics

    29 publications · 2K citations

    21

    h-index

  3. Clinical Pharmacology & Therapeutics

    CPT · 19 publications · 910 citations

    18

    h-index

  4. PLoS ONE

    19 publications · 784 citations

    15

    h-index

  5. CPT Pharmacometrics & Systems Pharmacology

    PSP · 22 publications · 732 citations

    15

    h-index

1–5