Ashley Robshaw

Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

Antonia F. Stepan, Chakrapani Subramanyam, Ivan Efremov et al. · Journal of Medicinal Chemistry · 2012 · 446 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Metabolism-Directed Design of Oxetane-Containing Arylsulfonamide Derivatives as γ-Secretase Inhibitors

Antonia F. Stepan, Kapil Karki, W. Scott McDonald et al. · Journal of Medicinal Chemistry · 2011 · 106 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

Michael A. Brodney, Elizabeth M. Beck, Christopher R. Butler et al. · Journal of Medicinal Chemistry · 2015 · 78 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Alternative method of oral administration by peanut butter pellet formulation results in target engagement of BACE1 and attenuation of gavage-induced stress responses in mice

Cathleen Gonzales, Margaret M. Zaleska, David Riddell et al. · Pharmacology Biochemistry and Behavior · 2014 · 58 citations

Pharmacy, Nutritional Sciences, Pharmacology +8

Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design

Christopher R. Butler, Michael A. Brodney, Elizabeth Beck et al. · Journal of Medicinal Chemistry · 2015 · 46 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17