CYP2C8 Activity Recovers within 96 Hours after Gemfibrozil Dosing: Estimation of CYP2C8 Half-Life Using Repaglinide as an in Vivo Probe

Mechanism-Based Inactivation of Human Cytochrome P450 Enzymes and the Prediction of Drug-Drug Interactions

R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan · Drug Metabolism and Disposition · 2006 · 456 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Gemfibrozil and Its Glucuronide Inhibit the Organic Anion Transporting Polypeptide 2 (OATP2/OATP1B1:SLC21A6)-Mediated Hepatic Uptake and CYP2C8-Mediated Metabolism of Cerivastatin: Analysis of the Mechanism of the Clinically Relevant Drug-Drug Interaction between Cerivastatin and Gemfibrozil

Yoshihisa Shitara, Masaru Hirano, Hitoshi Sato et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 405 citations

Medicine, Pharmacokinetics, Pharmacology +17

Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8.

Atiqur Rahman, Ken Korzekwa, James Grogan et al. · PubMed · 1994 · 391 citations

Medicine, Biochemistry, Pharmacology +17

Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics

Mikko Niemi, Janne T. Backman, Lauri Kajosaari et al. · Clinical Pharmacology & Therapeutics · 2005 · 361 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Gemfibrozil greatly increases plasma concentrations of cerivastatin

Janne T. Backman · Clinical Pharmacology & Therapeutics · 2002 · 336 citations

Pharmacy, Pharmacokinetics, Pharmacology +12