Concepedia

Exploiting sequence space: shuffling in vivo formed complementarity determining regions into a master framework

Pernilla Jirholt, Mats Ohlin, Carl Borrebaeck, Eskil Söderlind

Gene · 1998 · 84 citations · 16 references

DOI

Concepts

References

16

Rapid evolution of a protein in vitro by DNA shuffling

Willem P.C. Stemmer · Nature · 1994 · 1.9K citations

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Isolation of high affinity human antibodies directly from large synthetic repertoires.

Andrew D. Griffiths, Samuel C. Williams, Oliver Hartley et al. · The EMBO Journal · 1994 · 974 citations · Full text

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Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase

Kenneth R. Tindall, Thomas A. Kunkel · Biochemistry · 1988 · 810 citations

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Molecular evolution by staggered extension process (StEP) in vitro recombination

Huimin Zhao, Lori Giver, Zhixin Shao et al. · Nature Biotechnology · 1998 · 763 citations

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By-passing immunisation

Hennie R. Hoogenboom, Greg Winter · Journal of Molecular Biology · 1992 · 432 citations