Rapid evolution of a protein in vitro by DNA shuffling

Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase

Craig Tuerk, Larry Gold · Science · 1990 · 10.2K citations

Exponential Enrichment, Bacteriophage, Molecular Biology +17

Genetic Algorithms

John H. Holland · Scientific American · 1992 · 5.1K citations

Phage antibodies: filamentous phage displaying antibody variable domains

John McCafferty, Andrew D. Griffiths, Greg Winter et al. · Nature · 1990 · 2.4K citations

Phage Biology, Immunology, Antibody Engineering +4

Randomization of genes by PCR mutagenesis.

R C Cadwell, Gerald F. Joyce · Genome Research · 1992 · 1.1K citations · Full text

Random Point Mutations, Engineering, Reverse Genetics +17

Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda

William D. Huse, Lakshmi Sastry, Sheila A. Iverson et al. · Science · 1989 · 805 citations

Engineering, Humoral Response, Immunology +24