Concepedia

Sequence Space Exploration

Sequence Space Exploration is a methodological framework in computational biology and bioinformatics that enables the systematic traversal and sampling of the vast combinatorial space of biological sequences to identify functional variants, distinguished from related approaches by its explicit focus on generating and evaluating diverse, novel sequences within a high-dimensional sequence landscape.

502

Publications

37K

Citations

2.1K

Authors

725

Institutions

Publications per year

2017–2026

215

Parents

Publications

502

Protein 3D Structure Computed from Evolutionary Sequence Variation

Debora S. Marks, Lucy J. Colwell, Robert P. Sheridan et al. · PLoS ONE · 2011 · 1.2K citations · Full text

, , +13

Repetitive Elements May Comprise Over Two-Thirds of the Human Genome

A. P. Jason de Koning, Wanjun Gu, Todd A. Castoe et al. · PLoS Genetics · 2011 · 1.1K citations · Full text

, , +10

Large language models generate functional protein sequences across diverse families

Ali Madani, Ben Krause, Eric R. Greene et al. · Nature Biotechnology · 2023 · 1.1K citations · Full text

, , +16

Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity

Stefanie Urlinger, Udo Baron, Marion Thellmann et al. · Proceedings of the National Academy of Sciences · 2000 · 943 citations

, , +16

From sequences to shapes and back: a case study in RNA secondary structures

Peter Schuster, Walter Fontana, Peter F. Stadler et al. · Proceedings of the Royal Society B Biological Sciences · 1994 · 860 citations

, , +12

1–5 of 502

Authors

2.1K

  1. PF
    Peter F. Stadler

    Leipzig University, Germany

    5 publications · 1.8K citations

    6

    h-index

  2. FH
    Florian Hollfelder

    University of Cambridge, United Kingdom

    5 publications · 451 citations

    6

    h-index

  3. PA
    Philip A. Romero

    University of Wisconsin–Madison, United States

    4 publications · 251 citations

    5

    h-index

  4. EB
    Erich Bornberg‐Bauer

    University of Münster, Germany

    5 publications · 471 citations

    5

    h-index

  5. CB
    Chris Bailey‐Kellogg

    Dartmouth College, United States

    5 publications · 110 citations

    5

    h-index

1–5 of 2.1K

Institutions

725

  1. Harvard University

    Cambridge, United States

    21 h-index

    81 publications

    9.3K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    17 h-index

    72 publications

    4.7K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    16 h-index

    32 publications

    5.1K citations

  4. Stanford University

    Stanford, United States

    13 h-index

    58 publications

    8.8K citations

  5. Massachusetts Institute of Technology

    Cambridge, United States

    12 h-index

    42 publications

    1.7K citations

  6. Princeton University

    Princeton, United States

    12 h-index

    45 publications

    1.6K citations

  7. University of Washington

    Seattle, United States

    11 h-index

    48 publications

    5.2K citations

  8. University of California, San Francisco

    San Francisco, United States

    11 h-index

    30 publications

    5.8K citations

1–8 of 725

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 32 publications · 5.5K citations

    28

    h-index

  2. Nucleic Acids Research

    28 publications · 2.6K citations

    25

    h-index

  3. Nature Communications

    21 publications · 2K citations

    21

    h-index

  4. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 26 publications · 942 citations

    19

    h-index

  5. PLoS ONE

    14 publications · 2.1K citations

    13

    h-index

1–5