Ubiquitination and Degradation of Neuronal Nitric-Oxide Synthase in Vitro: Dimer Stabilization Protects the Enzyme from Proteolysis

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.

Avram Hershko, H Heller, Sarah Elias et al. · Journal of Biological Chemistry · 1983 · 1.1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide.

Kirk McMillan, David S. Bredt, D J Hirsch et al. · Proceedings of the National Academy of Sciences · 1992 · 368 citations · Full text

Life Sciences, Biochemistry, Neuroscience +8

Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L‐arginine in the formation of an SDS‐resistant dimer.

Peter Klatt, Kurt Schmidt, Dieter Lehner et al. · The EMBO Journal · 1995 · 293 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +6

High-level expression of functional rat neuronal nitric oxide synthase in Escherichia coli.

L. J. Roman, Essam A. Sheta, Pavel Martásek et al. · Proceedings of the National Academy of Sciences · 1995 · 238 citations

Life Sciences, Biochemistry, Molecular Biology +10

Degradation Signal Masking by Heterodimerization of MATα2 and MATa1 Blocks Their Mutual Destruction by the Ubiquitin-Proteasome Pathway

Phoebe Johnson, Robert Swanson, Larissa Rakhilina et al. · Cell · 1998 · 199 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +11