Concepedia

Utility of MetaSite in Improving Metabolic Stability of the Neutral Indomethacin Amide Derivative and Selective Cyclooxygenase-2 Inhibitor 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-phenethyl-acetamide

David Boyer, Jonathan Bauman, Daniel P. Walker, Brendon Kapinos, Kapil Karki, Amit S. Kalgutkar

Drug Metabolism and Disposition · 2009 · 25 citations · 18 references

DOI

Concepts

References

18

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

, , +17

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.

David C. Dahlin, Gerald T. Miwa, Albert Lu et al. · Proceedings of the National Academy of Sciences · 1984 · 1.1K citations

, , +16

MetaSite:  Understanding Metabolism in Human Cytochromes from the Perspective of the Chemist

Gabriele Cruciani, Emanuele Carosati, Benoît De Boeck et al. · Journal of Medicinal Chemistry · 2005 · 491 citations

, , +17

Ester and Amide Derivatives of the Nonsteroidal Antiinflammatory Drug, Indomethacin, as Selective Cyclooxygenase-2 Inhibitors

Amit S. Kalgutkar, Alan B. Marnett, Brenda C. Crews et al. · Journal of Medicinal Chemistry · 2000 · 312 citations · Full text

, , +11

Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: Facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors

Amit S. Kalgutkar, Brenda C. Crews, Scott W. Rowlinson et al. · Proceedings of the National Academy of Sciences · 2000 · 252 citations

, , +15