David Boyer

Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists

Paul S. Humphries, John W. Benbow, Paul D. Bonin et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 51 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12

(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: A potent, selective, orally active dipeptidyl peptidase IV inhibitor

Mark Ammirati, Kim Andrews, David Boyer et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 43 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7

Discovery of triazolopyrimidine-based PDE8B inhibitors: Exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes

Michael P. DeNinno, Stephen W. Wright, John B. Etienne et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 28 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

1,5-Substituted nipecotic amides: Selective PDE8 inhibitors displaying diastereomer-dependent microsomal stability

Michael P. DeNinno, Stephen W. Wright, Michael Visser et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 27 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7

Utility of MetaSite in Improving Metabolic Stability of the Neutral Indomethacin Amide Derivative and Selective Cyclooxygenase-2 Inhibitor 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-phenethyl-acetamide

David Boyer, Jonathan Bauman, Daniel P. Walker et al. · Drug Metabolism and Disposition · 2009 · 25 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17