Intracellular Accumulation of Amyloidogenic Fragments of Amyloid-β Precursor Protein in Neurons with Niemann-Pick Type C Defects Is Associated with Endosomal Abnormalities

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

Maj-Linda B. Selenica, Milene L. Brownlow, Jeffy P. Jimenez et al. · Neurodegenerative Diseases · 2012 · 10.4K citations · Full text

Life Sciences, Neurology, Neuroscience +17

Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

Gregory J. Brewer, John R. Torricelli, E. K. Evege et al. · Journal of Neuroscience Research · 1993 · 2.3K citations

Life Sciences, Neurobiology, Neuroscience +11

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

Mikael Simons, Patrick Keller, Bart De Strooper et al. · Proceedings of the National Academy of Sciences · 1998 · 1.2K citations

Life Sciences, Biochemistry, Neuroscience +17

Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 <i>in vitro</i> and <i>in vivo</i>

Mikael Simons, Christine Bergmann, Mark Stroick et al. · Proceedings of the National Academy of Sciences · 2001 · 1.1K citations · Full text

Life Sciences, Neuroscience, Pharmacology +15

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

David Borchelt, Tamara Ratovitski, Judy van Lare et al. · Neuron · 1997 · 1K citations

Life Sciences, Neurology, Neuroscience +17