Slow Amyloid Nucleation via α-Helix-Rich Oligomeric Intermediates in Short Polyglutamine-Containing Huntingtin Fragments

Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

Peter Schuck · Biophysical Journal · 2000 · 4K citations · Full text

Natural Sciences, Biophysics, Molecular Biology +10

Estimation of Protein Secondary Structure from Circular Dichroism Spectra: Comparison of CONTIN, SELCON, and CDSSTR Methods with an Expanded Reference Set

Narasimha Sreerama, Robert W. Woody · Analytical Biochemistry · 2000 · 3K citations

Life Sciences, Biochemistry, Biophysics +17

Nucleated Conformational Conversion and the Replication of Conformational Information by a Prion Determinant

Tricia R. Serio, Anil G. Cashikar, Anthony S. Kowal et al. · Science · 2000 · 964 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in <i>Caenorhabditis</i> <i>elegans</i>

James F. Morley, Heather R. Brignull, Jill J. Weyers et al. · Proceedings of the National Academy of Sciences · 2002 · 831 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: Implications for Huntington’s disease pathology

Eberhard Scherzinger, Annie Sittler, Katja Schweiger et al. · Proceedings of the National Academy of Sciences · 1999 · 729 citations

Life Sciences, Biochemistry, Molecular Biology +17