CD4+CD25+ T regulatory cells inhibit cytotoxic activity of T CD8+ and NK lymphocytes in the direct cell-to-cell interaction

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Jung‐Hyun Park, Stanley Adoro, Terry I. Guinter et al. · Nature Immunology · 2010 · 5.8K citations · Full text

Life Sciences, Cell Biology, Immunology +17

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Shimon Sakaguchi, N Sakaguchi, M Asano et al. · The Journal of Immunology · 1995 · 5.5K citations

Life Sciences, Immunology, Pathology +17

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

Hervé Groux, Anne O’Garra, Mike Bigler et al. · Nature · 1997 · 3.6K citations

Life Sciences, Immunology, Pathology +12

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

Angela M. Thornton, Ethan M. Shevach · The Journal of Experimental Medicine · 1998 · 2.6K citations · Full text

Life Sciences, Cell Biology, Immunology +17

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

Deborah J. Lenschow, Lesley Rhee, Neda Ashourian et al. · Immunity · 2000 · 2K citations · Full text

Life Sciences, Cell Biology, Immunology +16