Concepedia

A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines 1 1Edited by A. R. Fersht

Patrick Chêne, Jean Fuchs, Jacqueline A. Bohn, Carlos Garcı́a-Echeverrı́a, Pascal Furet, Doriano Fabbro

Journal of Molecular Biology · 2000 · 141 citations · 29 references

DOI

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29

WAF1, a potential mediator of p53 tumor suppression

Wafik S. El‐Deiry, Takashi Tokino, Victor E. Velculescu et al. · Cell · 1993 · 8.4K citations

, , +13

Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations

, , +10

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Donald W. Nicholson, Ambereen Ali, Nancy A. Thornberry et al. · Nature · 1995 · 4K citations

, , +13

Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden · Nature · 1997 · 3.3K citations

, , +10

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Jamil Momand, Gerard P. Zambetti, David C. Olson et al. · Cell · 1992 · 3.1K citations

, , +10