Patrick Chêne

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent <i>in vivo</i> antitumor activity

Sauveur-Michel Maira, Frédéric Stauffer, Josef Brueggen et al. · Molecular Cancer Therapeutics · 2008 · 1.1K citations · Full text

Medicine, Oncology, Pharmacology +13

Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

Sauveur-Michel Maira, Sabina Pecchi, Alan Huang et al. · Molecular Cancer Therapeutics · 2011 · 529 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Characterization of the Novel and Specific PI3Kα Inhibitor NVP-BYL719 and Development of the Patient Stratification Strategy for Clinical Trials

Christine Fritsch, Alan Huang, Christian Chatenay‐Rivauday et al. · Molecular Cancer Therapeutics · 2014 · 496 citations

Medicine, Oncology, Pharmacology +16

Molecular characterization of the hdm2-p53 interaction 1 1Edited by J. Karn

Angelika Böttger, Volker Böttger, Carlos Garcı́a-Echeverrı́a et al. · Journal of Molecular Biology · 1997 · 256 citations

Life Sciences, Molecular Biology, Oncology +16

Discovery of Potent Antagonists of the Interaction between Human Double Minute 2 and Tumor Suppressor p53

Carlos Garcı́a-Echeverrı́a, Patrick Chêne, Marcel J. J. Blommers et al. · Journal of Medicinal Chemistry · 2000 · 241 citations

Medicine, Oncology, Pharmacology +6