Carlos Garcı́a-Echeverrı́a

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

Jeffrey A. Engelman, Liang Chen, Xiaohong Tan et al. · Nature Medicine · 2008 · 1.3K citations · Full text

Medicine, Oncology, Pharmacology +17

NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

Violeta Serra, Ben Markman, Maurizio Scaltriti et al. · Cancer Research · 2008 · 796 citations · Full text

Medicine, Oncology, Pharmacology +16

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

Constantine S. Mitsiades, Nicholas Mitsiades, Ciaran J. McMullan et al. · Cancer Cell · 2004 · 611 citations

Medicine, Hematology, Oncology +17

The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations

Anna Dubrovska, Sungeun Kim, Richard J. Salamone et al. · Proceedings of the National Academy of Sciences · 2008 · 563 citations · Full text

Medicine, Cell Biology, Oncology +17

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

Silvia Buonamici, Juliet Williams, Michael Morrissey et al. · Science Translational Medicine · 2010 · 554 citations

Medicine, Oncology, Pharmacology +16