Metabolic Signature Genes Associated with Susceptibility to Pyruvate Kinase, Muscle Type 2 Gene Ablation in Cancer Cells

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Jung‐whan Kim, Irina Tchernyshyov, Gregg L. Semenza et al. · Cell Metabolism · 2006 · 3.9K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk, Matthew G. Vander Heiden, Marian H. Harris et al. · Nature · 2008 · 2.8K citations

Medicine, Cancer Biology, Oncology +16

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

Arun Sreekumar, Laila Poisson, Thekkelnaycke M. Rajendiran et al. · Nature · 2009 · 2.2K citations · Full text

Medicine, Cancer Biology, Oncology +16

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Ping Gao, Irina Tchernyshyov, Tsung-Cheng Chang et al. · Nature · 2009 · 2.1K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

David R. Wise, Ralph J. DeBerardinis, Anthony Mancuso et al. · Proceedings of the National Academy of Sciences · 2008 · 2K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17