The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity

The CCP4 suite: programs for protein crystallography

Number Collaborative Computational Project · Acta Crystallographica Section D Biological Crystallography · 1994 · 17.3K citations

X-ray Crystallography, Ccp4 Suite, Biochemistry +13

Improved methods for building protein models in electron density maps and the location of errors in these models

T. Alwyn Jones, Jin-yu Zou, Sandra W. Cowan et al. · Acta Crystallographica Section A Foundations of Crystallography · 1991 · 12.6K citations

Map Interpretation, Structural Bioinformatics, Biomolecular Structure Prediction +16

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

Axel T. Brünger · Nature · 1992 · 3.9K citations

Materials Science, Crystal Structure, Engineering +14

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

Wolfgang Kabsch · Journal of Applied Crystallography · 1993 · 3.6K citations

X-ray Crystallography, Crystal Structure, Engineering +18

Automated protein model building combined with iterative structure refinement.

Anastassis Perrakis, Richard J. Morris, Victor S. Lamzin · Nature Structural Biology · 1999 · 2.4K citations

Molecular Biology, Protein Modeling, Protein Structure Prediction +3