Concepedia

Loop Gating

Loop Gating is a dynamic regulatory mechanism in enzyme active site architecture wherein conformational changes in flexible loop regions selectively control substrate access to the catalytic core through transient structural rearrangements.

18

Publications

748

Citations

102

Authors

41

Institutions

Publications per year

2017–2026

5

Parents

Publications

18

Metal-tetracycline/H+ antiporter of Escherichia coli encoded by transposon Tn10. The role of a conserved sequence motif, GXXXXRXGRR, in a putative cytoplasmic loop between helices 2 and 3.

Akihito Yamaguchi, Yuichi Someya, Tetsuo Sawai · Journal of Biological Chemistry · 1992 · 105 citations · Full text

, , +13

Divalent Cations Regulate Connexin Hemichannels by Modulating Intrinsic Voltage-dependent Gating

Vytas K. Verselis, Miduturu Srinivas · The Journal of General Physiology · 2008 · 94 citations · Full text

, , +17

Loop Gating of Connexin Hemichannels Involves Movement of Pore-lining Residues in the First Extracellular Loop Domain

Vytas K. Verselis, M. Pilar Trelles, Clio Rubiños et al. · Journal of Biological Chemistry · 2008 · 88 citations · Full text

, , +17

Conformational changes in a pore-forming region underlie voltage-dependent “loop gating” of an unapposed connexin hemichannel

Qingxiu Tang, Terry L. Dowd, Vytas K. Verselis et al. · The Journal of General Physiology · 2009 · 64 citations · Full text

, , +16

Voltage-gating of Escherichia coli porin: a cystine-scanning mutagenesis study of loop 3 1 1Edited by I. B. Holland

Graeme Bainbridge, Hamid Mobasheri, Geoffrey A. Armstrong et al. · Journal of Molecular Biology · 1998 · 63 citations

, , +11

1–5 of 18

Authors

102

  1. VK
    Vytas K. Verselis

    Albert Einstein College of Medicine, United States

    5 publications · 321 citations

    5

    h-index

  2. MS
    Miduturu Srinivas

    Albert Einstein College of Medicine, United States

    4 publications · 257 citations

    4

    h-index

  3. VB
    Volkmar Braun

    University of Tübingen, Germany

    3 publications · 72 citations

    3

    h-index

  4. TA
    Thaddeus A. Bargiello

    Albert Einstein College of Medicine, United States

    2 publications · 152 citations

    2

    h-index

  5. NS
    Nefeli Slavi

    SUNY College of Optometry, United States

    2 publications · 75 citations

    2

    h-index

1–5 of 102

Institutions

41

  1. Albert Einstein College of Medicine

    Bronx, United States

    5 h-index

    10 publications

    612 citations

  2. SUNY College of Optometry

    New York, United States

    4 h-index

    8 publications

    508 citations

  3. University of Tübingen

    Tübingen, Germany

    3 h-index

    8 publications

    194 citations

  4. North Carolina State University

    Raleigh, United States

    2 h-index

    6 publications

    96 citations

  5. University of Virginia

    Charlottesville, United States

    2 h-index

    5 publications

    120 citations

  6. Institute of Molecular Life Sciences

    Budapest, Hungary

    1 h-index

    4 publications

    144 citations

  7. Chiba University

    Chiba, Japan

    1 h-index

    3 publications

    315 citations

  8. Semmelweis University

    Budapest, Hungary

    1 h-index

    1 publications

    36 citations

1–8 of 41

Venues

  1. Journal of Biological Chemistry

    JBC · 3 publications · 234 citations

    3

    h-index

  2. The Journal of General Physiology

    JGP · 3 publications · 192 citations

    3

    h-index

  3. FEBS Journal

    2 publications · 38 citations

    2

    h-index

  4. Journal of Bacteriology

    JB · 2 publications · 62 citations

    2

    h-index

  5. Journal of Molecular Biology

    JMB · 1 publications · 63 citations

    1

    h-index

1–5