Concepedia

Active Site Architecture

Active Site Architecture is the three-dimensional structural and physicochemical organization of the amino acid residues, cofactors, and other structural elements that constitute an enzyme’s active site and thereby determine its substrate binding, catalytic mechanism, and specificity.

2.8K

Publications

173.8K

Citations

10.5K

Authors

1.9K

Institutions

Publications per year

2017–2026

288

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Children

Publications

2.8K

On the size of the active site in proteases. I. Papain

Israël Schechter, Arieh Berger · Biochemical and Biophysical Research Communications · 1967 · 5.2K citations

, , +9

Atomic Structure of Acetylcholinesterase from <i>Torpedo californica</i> : A Prototypic Acetylcholine-Binding Protein

Joel L. Sussman, Michal Harel, Felix Frolow et al. · Science · 1991 · 2.7K citations

, , +17

Three-dimensional structure of calmodulin

Y.S. Babu, John S. Sack, Trevor J. Greenhough et al. · Nature · 1985 · 1K citations

, , +11

Boosting Oxygen Reduction of Single Iron Active Sites via Geometric and Electronic Engineering: Nitrogen and Phosphorus Dual Coordination

Kai Yuan, Dirk Lützenkirchen−Hecht, Longbin Li et al. · Journal of the American Chemical Society · 2020 · 1K citations · Full text

, , +17

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

Daniel R. Knighton, Jianhua Zheng, Lynn F. Ten Eyck et al. · Science · 1991 · 963 citations

, , +17

1–5 of 2.8K

Authors

10.5K

  1. CT
    Claudiu T. Supuran

    University of Florence, Italy

    18 publications · 2.1K citations

    18

    h-index

  2. DN
    David N. Silverman

    University of Florida, United States

    19 publications · 746 citations

    15

    h-index

  3. JP
    Judith P. Klinman

    University of California, Berkeley, United States

    15 publications · 1.9K citations

    15

    h-index

  4. RM
    Robert McKenna

    University of Florida, United States

    16 publications · 796 citations

    14

    h-index

  5. IF
    Ignacio Fita

    Institut de Biologia Molecular de Barcelona, Spain

    14 publications · 1.1K citations

    13

    h-index

1–5 of 10.5K

Institutions

1.9K

  1. Centre National de la Recherche Scientifique

    Paris, France

    45 h-index

    350 publications

    29.6K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    43 h-index

    178 publications

    15.4K citations

  3. Scripps Research Institute

    San Diego, United States

    30 h-index

    173 publications

    16.7K citations

  4. Stanford University

    Stanford, United States

    30 h-index

    146 publications

    9.7K citations

  5. University of California, Berkeley

    Berkeley, United States

    28 h-index

    116 publications

    11.2K citations

  6. Chinese Academy of Sciences

    Beijing, China

    25 h-index

    197 publications

    8.9K citations

  7. University of Minnesota

    Minneapolis, United States

    25 h-index

    90 publications

    4.4K citations

  8. Harvard University

    Cambridge, United States

    25 h-index

    67 publications

    7.2K citations

1–8 of 1.9K

Venues

  1. Biochemistry

    350 publications · 19.6K citations

    73

    h-index

  2. Journal of Biological Chemistry

    JBC · 240 publications · 16.8K citations

    70

    h-index

  3. Journal of Molecular Biology

    JMB · 150 publications · 11.8K citations

    60

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 76 publications · 8.3K citations

    54

    h-index

  5. Journal of the American Chemical Society

    JACS · 109 publications · 7.9K citations

    50

    h-index

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