Concepedia

Active Site Evolution

Active Site Evolution is a theoretical construct in enzymology that delineates the mechanistic and structural modifications of enzyme active sites over evolutionary time, distinguishing it from broader evolutionary analyses by focusing specifically on functional residue divergence and conservation underlying catalytic specificity and efficiency.

203

Publications

13.4K

Citations

896

Authors

326

Institutions

Publications per year

2017–2026

50

Parents

Publications

203

An evolutionary treasure: unification of a broad set of amidohydrolases related to urease

Liisa Holm, Chris Sander · Proteins Structure Function and Bioinformatics · 1997 · 504 citations

, , +17

Evolutionary Genomics of the HAD Superfamily: Understanding the Structural Adaptations and Catalytic Diversity in a Superfamily of Phosphoesterases and Allied Enzymes

A. Maxwell Burroughs, Karen N. Allen, Debra Dunaway‐Mariano et al. · Journal of Molecular Biology · 2006 · 458 citations

, , +14

Directed Evolution of Enantioselective Enzymes: Iterative Cycles of CASTing for Probing Protein‐Sequence Space

Manfred T. Reetz, Marco Bocola · Angewandte Chemie International Edition · 2006 · 362 citations

, , +17

Precision is essential for efficient catalysis in an evolved Kemp eliminase

Rebecca Blomberg, Hajo Kries, Daniel M. Pinkas et al. · Nature · 2013 · 347 citations · Full text

, , +14

Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes

Dong‐Sun Lee, Pierre Nioche, Mats Hámberg et al. · Nature · 2008 · 292 citations

, , +16

1–5 of 203

Authors

896

  1. CJ
    Colin J. Jackson

    Australian National University, Australia

    11 publications · 749 citations

    11

    h-index

  2. SC
    Shina Caroline Lynn Kamerlin

    Uppsala University, Sweden

    7 publications · 437 citations

    7

    h-index

  3. DS
    Dan S. Tawfik

    Weizmann Institute of Science, Israel

    5 publications · 510 citations

    5

    h-index

  4. PD
    Paul D. Carr

    Australian National University, Australia

    5 publications · 300 citations

    5

    h-index

  5. NT
    Nobuhiko Tokuriki

    Canada's Michael Smith Genome Sciences Centre, Canada

    5 publications · 319 citations

    5

    h-index

1–5 of 896

Institutions

326

  1. Australian National University

    Canberra, Australia

    11 h-index

    45 publications

    3K citations

  2. Uppsala University

    Uppsala, Sweden

    10 h-index

    24 publications

    1.7K citations

  3. Weizmann Institute of Science

    Rehovot, Israel

    8 h-index

    18 publications

    1.5K citations

  4. University of British Columbia

    Vancouver, Canada

    6 h-index

    11 publications

    644 citations

  5. Texas A&M University

    College Station, United States

    6 h-index

    31 publications

    1.8K citations

  6. University of California, Berkeley

    Berkeley, United States

    6 h-index

    24 publications

    2.1K citations

  7. University College London

    London, United Kingdom

    5 h-index

    13 publications

    525 citations

  8. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    14 publications

    1.4K citations

1–8 of 326

Venues

  1. Biochemistry

    22 publications · 1.2K citations

    17

    h-index

  2. Journal of Molecular Biology

    JMB · 15 publications · 1.2K citations

    14

    h-index

  3. Journal of Biological Chemistry

    JBC · 12 publications · 839 citations

    12

    h-index

  4. Journal of the American Chemical Society

    JACS · 9 publications · 520 citations

    9

    h-index

  5. Nature

    7 publications · 1.3K citations

    7

    h-index

1–5