Concepedia

Active Site Conservation

Active Site Conservation is a biochemical principle denoting the preservation of specific amino acid residues and structural motifs within an enzyme's catalytic region that are essential for maintaining substrate binding and catalytic function across evolutionary homologs.

52

Publications

3.1K

Citations

217

Authors

91

Institutions

Publications per year

2017–2026

9

Parents

Publications

52

Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation.

Thierry Fischmann, Alan Hruza, Xiao Da Niu et al. · Nature Structural Biology · 1999 · 456 citations

, , +10

Active Site Flexibility as a Hallmark for Efficient PET Degradation by I. sakaiensis PETase

Tobias Fecker, Pablo Galaz‐Davison, Felipe Engelberger et al. · Biophysical Journal · 2018 · 289 citations

, , +13

The structure of L‐amino acid oxidase reveals the substrate trajectory into an enantiomerically conserved active site

Peter D. Pawelek · The EMBO Journal · 2000 · 267 citations · Full text

, , +16

Convergent Evolution of Enzyme Active Sites Is not a Rare Phenomenon

Pier Federico Gherardini, Mark N. Wass, Manuela Helmer‐Citterich et al. · Journal of Molecular Biology · 2007 · 137 citations

, , +16

Substrate-induced remodeling of the active site regulates human HTRA1 activity

Linda Truebestein, Annette Tennstaedt, Timon Mönig et al. · Nature Structural & Molecular Biology · 2011 · 132 citations

, , +10

1–5 of 52

Authors

217

  1. JP
    Judith P. Klinman

    University of California, Berkeley, United States

    3 publications · 83 citations

    3

    h-index

  2. MK
    Mahendra Kumar Jain

    University of Delaware, United States

    2 publications · 106 citations

    2

    h-index

  3. MT
    Ming‐Daw Tsai

    The Ohio State University, United States

    2 publications · 106 citations

    2

    h-index

  4. JL
    Jennifer L. DuBois

    Montana State University, United States

    2 publications · 43 citations

    2

    h-index

  5. JP
    John Perozich

    University of Pittsburgh, United States

    1 publications · 94 citations

    1

    h-index

1–5 of 217

Institutions

91

  1. University of California, Berkeley

    Berkeley, United States

    4 h-index

    10 publications

    452 citations

  2. The Ohio State University

    Columbus, United States

    3 h-index

    5 publications

    667 citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    14 publications

    1.2K citations

  4. McGill University

    Montreal, Canada

    2 h-index

    5 publications

    835 citations

  5. Institut de Biologie Structurale

    Grenoble, France

    2 h-index

    10 publications

    649 citations

  6. University of California, Davis

    Davis, United States

    2 h-index

    4 publications

    92 citations

  7. University of Wisconsin–Madison

    Madison, United States

    1 h-index

    8 publications

    392 citations

  8. Daegu University

    Daegu, South Korea

    1 h-index

    3 publications

    42 citations

1–8 of 91

Venues

  1. Biochemistry

    12 publications · 482 citations

    11

    h-index

  2. Journal of Biological Chemistry

    JBC · 4 publications · 223 citations

    4

    h-index

  3. Journal of the American Chemical Society

    JACS · 3 publications · 137 citations

    3

    h-index

  4. The Journal of Biochemistry

    JB · 2 publications · 54 citations

    2

    h-index

  5. Protein Science

    PS · 2 publications · 143 citations

    2

    h-index

1–5