The extracellular-regulated protein kinase 5 (ERK5) promotes cell proliferation through the down-regulation of inhibitors of cyclin dependent protein kinases (CDKs)

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J. Wade Harper · Cell · 1993 · 5.6K citations

Molecular Pharmacology, G1 Cyclin-dependent Kinases, Signal Transduction +10

p21 is a universal inhibitor of cyclin kinases

Yue Xiong, Gregory J. Hannon, Hui Zhang et al. · Nature · 1993 · 3.4K citations

Receptor Tyrosine Kinase, Cyclin Kinases, Anti-cancer Agent +4

c-Myc-regulated microRNAs modulate E2F1 expression

Kathryn A. O’Donnell, Erik A. Wentzel, Karen Zeller et al. · Nature · 2005 · 2.6K citations

Microrna Detection, Medicine, Cell Biology +2

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

Kornélia Polyák, Mong-Hong Lee, Hediye Erdjument‐Bromage et al. · Cell · 1994 · 2.1K citations

Signal Transduction, Potential Mediator, Signaling Pathway +12

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

Hideo Toyoshima, Tony Hunter · Cell · 1994 · 2.1K citations

Novel Inhibitor, Signal Transduction, Cell Regulation +6