An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR

A Microassay for Measuring Cytochrome P450IA1 and Cytochrome P450IIB1 Activities in Intact Human and Rat Hepatocytes Cultured on 96-Well Plates

M. Teresa Donato, M. José Gómez‐Lechón, José V. Castell · Analytical Biochemistry · 1993 · 300 citations

Medicine, Biochemistry, Pharmacology +11

The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin

Janne T. Backman, Kari T. Kivistö, Klaus T. Olkkola et al. · European Journal of Clinical Pharmacology · 1998 · 269 citations

Medicine, Pharmacokinetics, Pharmacology +13

The Use of Human Hepatocyte Cultures to Study the Induction of Cytochrome P-450

Vsevolod E. Kostrubsky, Vinod Ramachandran, Raman Venkataramanan et al. · Drug Metabolism and Disposition · 1999 · 140 citations

Medicine, Biochemistry, Pharmacology +17

Cyclosporin A metabolism in human liver, kidney, and intestine slices. Comparison to rat and dog slices and human cell lines.

Alison E.M. Vickers, Volker Fischer, Sean Connors et al. · Drug Metabolism and Disposition · 1992 · 126 citations

Medicine, Biochemistry, Pharmacology +14

The Relationship Among Microsomal Enzyme Induction, Liver Weight and Histological Change in Rat Toxicology Studies

David E. Amacher, Shelli Schomaker, John E. Burkhardt · Food and Chemical Toxicology · 1998 · 123 citations

Pharmacy, Biochemistry, Toxicology +17