The Use of Human Hepatocyte Cultures to Study the Induction of Cytochrome P-450

Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.

Deborah J. Newton, R W Wang, Anthony Y.H. Lu · Drug Metabolism and Disposition · 1995 · 606 citations

Medicine, Pharmacokinetics, Pharmacology +17

Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

Lydiane Pichard, Isabelle Fabre, Gérard Fabre et al. · Drug Metabolism and Disposition · 1990 · 437 citations

Medicine, Pharmacology, Toxicology +17

Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P-450 enzyme

David J. Waxman, C Attisano, F. Peter Guengerich et al. · Archives of Biochemistry and Biophysics · 1988 · 415 citations

Life Sciences, Biochemistry, Hepatology +11

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3).

Steven Wrighton, W. Brian, M.-A. Sari et al. · Molecular Pharmacology · 1990 · 403 citations

Medicine, Biochemistry, Pharmacology +12

Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver.

David J. Waxman, Albert I. Ko, Christopher T. Walsh · Journal of Biological Chemistry · 1983 · 393 citations · Full text

Medicine, Biochemistry, Pharmacology +17