An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics

Luisella Vignati, Elisa Turlizzi, Sonia Monaci, +3

Toxicology

Metabolite ToxicityBiochemistryMedicineVitro ApproachCyp3a4-dependent Bioactivation +8

An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR

Marcella Martignoni, Ruben de Kanter, Pietro Grossi, +3

Chemico-Biological Interactions

HepatologyQuantitative Rt-pcrGastrointestinal PharmacologyLiver PhysiologyPhysiology +7

A human and mouse pregnane X receptor reporter gene assay in combination with cytotoxicity measurements as a tool to evaluate species-specific CYP3A induction

Luisella Vignati, Alessia Bogni, Pietro Grossi, +1

Toxicology

Knockout MouseMolecular PharmacologyReporter Gene AssayMedicineOncogenic Agent +7

Phase I and phase II metabolic activities are retained in liver slices from mouse, rat, dog, monkey and human after cryopreservation

Marcella Martignoni, Mario Monshouwer, Ruben de Kanter, +3

Toxicology in Vitro

Animal PhysiologyEnergy MetabolismBiochemistryLiver SlicesMedicine +11

An in vivo and in vitro comparison of CYP gene induction in mice using liver slices and quantitative RT-PCR

Marcella Martignoni, Ruben de Kanter, Pietro Grossi, +3

Toxicology in Vitro

HepatologyLiver SlicesQuantitative Rt-pcrLiver PhysiologyImmunology +6

Absorption, distribution and excretion of lacidipine, a dihydropyridine calcium antagonist, in rat and dog

Mario Pellegatti, Pietro Grossi, John Ayrton, +2

Xenobiotica

Predicting Myelosuppression of Drugs from in Silico Models

Patrizia Crivori, Giulia Pennella, M. Magistrelli, +2

Journal of Chemical Information and Modeling

Systems PharmacologyMedicinal ChemistryDrug TargetEngineeringMedicine +11

Assessing and managing toxicities induced by kinase inhibitors.

Raffaella Castoldi, Giulia Pennella, Grazia Saturno, +3

PubMed

Molecular PharmacologyKinase-modulating CompoundsSignal TransductionSignaling PathwayBiochemistry +13

Lack of strain-related differences in drug metabolism and efflux transporter characteristics between CD-1 and athymic nude mice

Marcella Martignoni, Ruben de Kanter, Anna Moscone, +2

Cancer Chemotherapy and Pharmacology

Molecular PharmacologyAthymic Nude MiceStrain-related DifferencesBiochemistryMedicine +4

Investigation into lacidipine and related metabolites by high-performance liquid chromatography—mass spectrometry

Paolo Rossato, M. Scandola, Pietro Grossi

Journal of Chromatography A

BiochemistryMedicineBioanalysisMass SpectrometryMetabolomic Profiling +8