Concepedia

Intestinal Enzyme Induction

Intestinal Enzyme Induction is a physiological process denoting the upregulation of enzyme expression in the intestinal epithelium, particularly cytochrome P450 enzymes and phase II conjugating enzymes, mediated by xenobiotic or dietary activators of nuclear receptors such as PXR and AhR, thereby enhancing the intestinal capacity for drug and xenobiotic metabolism.

139

Publications

8.6K

Citations

581

Authors

208

Institutions

Publications per year

2017–2026

17

Parents

Publications

139

Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

Anke Geick, Michel Eichelbaum, Oliver Burk · Journal of Biological Chemistry · 2001 · 841 citations · Full text

, , +12

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.

Joseph C. Kolars, Phyllissa Schmiedlin‐Ren, John D. Schuetz et al. · Journal of Clinical Investigation · 1992 · 533 citations · Full text

, , +14

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man.

Paul B. Watkins, Steven Wrighton, Erin G. Schuetz et al. · Journal of Clinical Investigation · 1987 · 483 citations · Full text

, , +13

The effect of milk and lactobacillus feeding on human intestinal bacterial enzyme activity

Barry R. Goldin, S. L. Gorbach · American Journal of Clinical Nutrition · 1984 · 399 citations

, , +14

Transcriptional Control of Intestinal Cytochrome P-4503A by 1α,25-Dihydroxy Vitamin D3

Kenneth E. Thummel, Cynthia Brimer, Kazuto Yasuda et al. · Molecular Pharmacology · 2001 · 324 citations

, , +17

1–5 of 139

Authors

581

  1. LA
    Laurie A. Jaeger

    Texas A&M University, United States

    4 publications · 113 citations

    4

    h-index

  2. CM
    Christopher M. Dekaney

    University of North Carolina at Chapel Hill, United States

    4 publications · 113 citations

    4

    h-index

  3. ME
    Michel Eichelbaum

    Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Germany

    3 publications · 1.1K citations

    3

    h-index

  4. LS
    Laurence S. Kaminsky

    New York State Department of Health, United States

    3 publications · 172 citations

    3

    h-index

  5. EG
    Erin G. Schuetz

    St. Jude Children's Research Hospital, United States

    3 publications · 837 citations

    3

    h-index

1–5 of 581

Institutions

208

  1. The University of Tokyo

    Tokyo, Japan

    4 h-index

    19 publications

    921 citations

  2. University of Groningen

    Groningen, The Netherlands

    4 h-index

    13 publications

    277 citations

  3. New York State Department of Health

    Albany, United States

    3 h-index

    6 publications

    223 citations

  4. Osaka University of Pharmaceutical Sciences

    Takatsuki, Japan

    3 h-index

    11 publications

    465 citations

  5. University of Washington

    Seattle, United States

    3 h-index

    21 publications

    3.6K citations

  6. The University of Osaka

    Osaka, Japan

    3 h-index

    6 publications

    198 citations

  7. University of Michigan

    Ann Arbor, United States

    3 h-index

    17 publications

    3.8K citations

  8. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology

    Stuttgart, Germany

    3 h-index

    10 publications

    3.5K citations

1–8 of 208

Venues

  1. PubMed

    Repository · 8 publications · 371 citations

    8

    h-index

  2. Pediatric Research

    7 publications · 360 citations

    7

    h-index

  3. Drug Metabolism and Disposition

    7 publications · 501 citations

    7

    h-index

  4. 6

    h-index

  5. Biochemical and Biophysical Research Communications

    BBRC · 6 publications · 255 citations

    6

    h-index

1–5