Phyllissa Schmiedlin‐Ren

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*

Kenneth S. Lown, Robert R. Mayo, Alan B. Leichtman et al. · Clinical Pharmacology & Therapeutics · 1997 · 682 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.

Joseph C. Kolars, Phyllissa Schmiedlin‐Ren, John D. Schuetz et al. · Journal of Clinical Investigation · 1992 · 533 citations · Full text

Medicine, Molecular Biology, Pharmacology +14

CYP3A gene expression in human gut epithelium

Joseph C. Kolars, Kenneth S. Lown, Phyllissa Schmiedlin‐Ren et al. · Pharmacogenetics · 1994 · 369 citations

Life Sciences, Biochemistry, Molecular Biology +11

Expression of Enzymatically Active CYP3A4 by Caco-2 Cells Grown on Extracellular Matrix-Coated Permeable Supports in the Presence of 1α,25-Dihydroxyvitamin D3

Phyllissa Schmiedlin‐Ren, Kenneth E. Thummel, Jeannine M. Fisher et al. · Molecular Pharmacology · 1997 · 329 citations

Medicine, Pharmacology, Bioavailability +12

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents: Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins

Paul F. Hollenberg, David Edwards, Kan He et al. · UNC Libraries · 2019 · 311 citations · Full text

Agriculture, Pharmacokinetics, Pharmacology +9