Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Jie Kang, Hans-Georg Lemaire, Axel Unterbeck et al. · Nature · 1987 · 4.6K citations

Life Sciences, Molecular Biology, Neuroscience +14

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Colin L. Masters, G. Simms, Nicola A. Weinman et al. · Proceedings of the National Academy of Sciences · 1985 · 4.4K citations · Full text

Life Sciences, Biochemistry, Neurology +17

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen et al. · Nature Medicine · 1996 · 2.6K citations

Life Sciences, Neurobiology, Neuroscience +16

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

Takeshi Iwatsubo, Asano Odaka, Nobuhiro Suzuki et al. · Neuron · 1994 · 1.8K citations

Life Sciences, Neuroscience, Pathology +16

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

David Borchelt, Gopal Thinakaran, Christopher B. Eckman et al. · Neuron · 1996 · 1.5K citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17