Concepedia

The optimization of aminooxadiazoles as orally active inhibitors of Cdc7

Paul E. Harrington, Matthew P. Bourbeau, Christopher Fotsch, Michael Frohn, Alexander J. Pickrell, Andreas Reichelt, Kelvin Sham, Aaron C. Siegmund, Julie M. Bailis, Tammy L. Bush,

Bioorganic & Medicinal Chemistry Letters · 2013 · 22 citations · 17 references

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Synthesis of Enantiomerically Pure <i>N</i>-<i>tert</i>-Butanesulfinyl Imines (<i>tert</i>-Butanesulfinimines) by the Direct Condensation of <i>tert</i>-Butanesulfinamide with Aldehydes and Ketones

Guangcheng Liu, Derek A. Cogan, Timothy D. Owens et al. · The Journal of Organic Chemistry · 1999 · 499 citations

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Mammalian Cdc7–Dbf4 protein kinase complex is essential for initiation of DNA replication

Wei Jiang, D McDonald, Thomas J. Hope et al. · The EMBO Journal · 1999 · 222 citations · Full text

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A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity

Alessia Montagnoli, Barbara Valsasina, Valter Croci et al. · Nature Chemical Biology · 2008 · 215 citations · Full text

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Cdc7 Inhibition Reveals a p53-Dependent Replication Checkpoint That Is Defective in Cancer Cells

Alessia Montagnoli, Pierluigi Tenca, Francesco Sola et al. · Cancer Research · 2004 · 140 citations · Full text

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Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships

Ermes Vanotti, Raffaella Amici, Alberto Bargiotti et al. · Journal of Medicinal Chemistry · 2008 · 94 citations · Full text

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