Alexander J. Pickrell

Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors

Brian A. Lanman, Jennifer R. Allen, John G. Allen et al. · Journal of Medicinal Chemistry · 2019 · 722 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +16

Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitors

Mike Frohn, Vellarkad N. Viswanadhan, Alexander J. Pickrell et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 25 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

The optimization of aminooxadiazoles as orally active inhibitors of Cdc7

Paul E. Harrington, Matthew P. Bourbeau, Christopher Fotsch et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 22 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

4-Methoxy-<i>N</i>-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P₁

Lewis D. Pennington, Kelvin Sham, Alexander J. Pickrell et al. · ACS Medicinal Chemistry Letters · 2011 · 20 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +15

Discovery of a Potent, S1P₃-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P₁)

Brian A. Lanman, Victor J. Cee, Srinivasa R. Cheruku et al. · ACS Medicinal Chemistry Letters · 2010 · 19 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16