Aaron C. Siegmund - Concepedia

Author

Aaron C. Siegmund

Amgen (United States)

Also Known As

Aaron C Siegmund, Aaron C. Siegmund

Publications

904

Citations

H-Index

Concepts

All Affiliations

Amgen (United States)

About

Aaron C. Siegmund is an author at Amgen (United States) specializing in medicinal chemistry, drug discovery, and natural sciences.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	3	3	735
2	Natural Sciences	3	3	735
3	Engineering	2	2	115
4	Biochemistry	2	2	58
5	Biomolecular Engineering	1	1	51

Aaron C. Siegmund

Publications

897

Citations

H-Index

Page 1

	Year	Citations
Discovery of a Covalent Inhibitor of KRAS<sup>G12C</sup> (AMG 510) for the Treatment of Solid Tumors Brian A. Lanman, Jennifer R. Allen, John G. Allen, Journal of Medicinal Chemistry Drug TargetSolid TumorsMolecular BiologyCryptic PocketChemical Biology	2019	677
Application of the sulfonamide functional group as an anchor for solid phase organic synthesis (SPOS) Krista A. Beaver, Aaron C. Siegmund, Kerry L. Spear Tetrahedron Letters Chemical EngineeringEngineeringOrganic ChemistrySulfonamide Functional GroupChemistry	1996	64
Solid phase organic synthesis (SPOS): A novel route to diketopiperazines and diketomorpholines Barbara O. Scott, Aaron C. Siegmund, Charles K. Marlowe, Molecular Diversity Combinatorial ChemistryDiversity Oriented SynthesisEngineeringNovel RouteOrganic Chemistry	1996	51
Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (n<sub>N</sub> → σ*<sub>S–X</sub>) Interaction for Conformational Constraint Lewis D. Pennington, Michael D. Bartberger, Michael D. Croghan, Journal of Medicinal Chemistry Molecular BiologyPeptide ScienceAnalytical UltracentrifugationChemical BiologyPharmaceutical Chemistry	2015	38
Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2 Liping H. Pettus, Matthew P. Bourbeau, Jodi Bradley, Journal of Medicinal Chemistry	2019	33
The optimization of aminooxadiazoles as orally active inhibitors of Cdc7 Paul E. Harrington, Matthew P. Bourbeau, Christopher Fotsch, Bioorganic & Medicinal Chemistry Letters Medicinal ChemistryBiochemistryMedicineActive InhibitorsNatural Sciences	2013	20
Imidazolone as an Amide Bioisostere in the Development of β-1,3-<i>N</i>-Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors Jeffrey J. Jackson, Aaron C. Siegmund, Wen‐Ju Bai, Journal of Medicinal Chemistry	2023	14

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