Aaron C. Siegmund

Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors

Brian A. Lanman, Jennifer R. Allen, John G. Allen et al. · Journal of Medicinal Chemistry · 2019 · 677 citations · Full text

Drug Target, Solid Tumors, Molecular Biology +20

Application of the sulfonamide functional group as an anchor for solid phase organic synthesis (SPOS)

Krista A. Beaver, Aaron C. Siegmund, Kerry L. Spear · Tetrahedron Letters · 1996 · 64 citations

Chemical Engineering, Engineering, Organic Chemistry +4

Solid phase organic synthesis (SPOS): A novel route to diketopiperazines and diketomorpholines

Barbara O. Scott, Aaron C. Siegmund, Charles K. Marlowe et al. · Molecular Diversity · 1996 · 51 citations

Combinatorial Chemistry, Diversity Oriented Synthesis, Engineering +5

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (n_N → σ*_S–X) Interaction for Conformational Constraint

Lewis D. Pennington, Michael D. Bartberger, Michael D. Croghan et al. · Journal of Medicinal Chemistry · 2015 · 38 citations · Full text

Molecular Biology, Peptide Science, Analytical Ultracentrifugation +22

Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2

Liping H. Pettus, Matthew P. Bourbeau, Jodi Bradley et al. · Journal of Medicinal Chemistry · 2019 · 33 citations · Full text