Michael D. Croghan

Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid

Matthew M. Weiss, Toni Williamson, Safura Babu‐Khan et al. · Journal of Medicinal Chemistry · 2012 · 64 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-dPhe-Arg-Trp-Lys]-NH2

Christopher Fotsch, D.M. Smith, Jeffrey A. Adams et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors

Thomas A. Dineen, Matthew M. Weiss, Toni Williamson et al. · Journal of Medicinal Chemistry · 2012 · 41 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +12

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (n_N → σ*_S–X) Interaction for Conformational Constraint

Lewis D. Pennington, Michael D. Bartberger, Michael D. Croghan et al. · Journal of Medicinal Chemistry · 2015 · 41 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept

Kate S. Ashton, Kristin L. Andrews, Marion C. Bryan et al. · Journal of Medicinal Chemistry · 2014 · 33 citations · Full text

Life Sciences, Biochemistry, Pharmacology +9