Kristin L. Andrews

Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors

Noel D. D’Angelo, Tae‐Seong Kim, Kristin L. Andrews et al. · Journal of Medicinal Chemistry · 2011 · 119 citations · Full text

Pharmacy, Oncology, Pharmacology +14

Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the Na_V1.7 Sodium Channel

Justin K. Murray, Joseph Ligutti, Dong Liu et al. · Journal of Medicinal Chemistry · 2015 · 117 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability

Paul E. Harrington, Kaustav Biswas, David J. Malwitz et al. · ACS Medicinal Chemistry Letters · 2014 · 104 citations · Full text

Life Sciences, Molecular Biology, Oncology +13

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

David J. Lloyd, David J. St. Jean, Robert J. Kurzeja et al. · Nature · 2013 · 98 citations

Life Sciences, Biochemistry, Pharmacology +14

Discovery and in Vivo Evaluation of (<i>S</i>)-<i>N</i>-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9<i>H</i>-purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease

Timothy D. Cushing, Xiaolin Hao, Youngsook Shin et al. · Journal of Medicinal Chemistry · 2014 · 86 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17