Kristin L. Andrews

Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors

Noel D. D’Angelo, Tae‐Seong Kim, Kristin L. Andrews et al. · Journal of Medicinal Chemistry · 2011 · 118 citations · Full text

Drug Target, Pharmacotherapy, Benzothiazole Phosphoinositide 3-Kinase +21

Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the Na_V1.7 Sodium Channel

Justin K. Murray, Joseph Ligutti, Dong Liu et al. · Journal of Medicinal Chemistry · 2015 · 116 citations · Full text

Molecular Pharmacology, 34-Residue Peptide, Nav Subtype Selectivity +14

Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability

Paul E. Harrington, Kaustav Biswas, David J. Malwitz et al. · ACS Medicinal Chemistry Letters · 2014 · 103 citations · Full text

Cellular Viability, Kinase Site, Protein Response +20

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

David J. Lloyd, David J. St. Jean, Robert J. Kurzeja et al. · Nature · 2013 · 96 citations

Biochemistry, Medicine, Insulin Management +6

Discovery and in Vivo Evaluation of (<i>S</i>)-<i>N</i>-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9<i>H</i>-purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease

Timothy D. Cushing, Xiaolin Hao, Youngsook Shin et al. · Journal of Medicinal Chemistry · 2014 · 84 citations

Pharmaceutical Science, Immune Regulation, Immunology +23