Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors

Noel D. D’Angelo, Tae‐Seong Kim, Kristin L. Andrews, +25

Journal of Medicinal Chemistry

Drug TargetPharmacotherapyBenzothiazole Phosphoinositide 3-KinaseChemical BiologyPharmaceutical Chemistry +19

Spectroscopic Studies of the Interaction of Methyl Orange with Cationic Alkyltrimethylammonium Bromide Surfactants

Kerry K. Karukstis, Daniel A. Savin, Christine T. Loftus, +1

Journal of Colloid and Interface Science

Chemical EngineeringChemical MeasurementEngineeringSpectroscopic StudiesChemical Property +5

Structure-Based Design of Novel Class II c-Met Inhibitors: 1. Identification of Pyrazolone-Based Derivatives

Mark H. Norman, Longbin Liu, Matthew Lee, +8

Journal of Medicinal Chemistry

Combinatorial ChemistryClass IiDrug TargetPharmaceutical ChemistryClass Ii Inhibitors +16

Design, Synthesis, and Biological Evaluation of Potent c-Met Inhibitors

Noel D. D’Angelo, Steven F. Bellon, Shon K. Booker, +23

Journal of Medicinal Chemistry

Molecular DockingMedicinal ChemistryDrug TargetPotent C-met InhibitorsBiochemistry +11

Discovery of 1<i>H</i>-Pyrazol-3(2<i>H</i>)-ones as Potent and Selective Inhibitors of Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK)

Adrian L. Smith, Kristin L. Andrews, Holger Beckmann, +20

Journal of Medicinal Chemistry

Drug TargetSelective InhibitorsMolecular PharmacologyMedicinal ChemistryStructure-based Design +15

Structure-Based Design of Novel Class II c-Met Inhibitors: 2. SAR and Kinase Selectivity Profiles of the Pyrazolone Series

Longbin Liu, Mark H. Norman, Matthew Lee, +16

Journal of Medicinal Chemistry

Drug TargetChemical BiologyPharmaceutical ChemistryTumor BiologyDrug Resistance +19

Selective Class I Phosphoinositide 3-Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511

Mark H. Norman, Kristin L. Andrews, Yunxin Bo, +34

Journal of Medicinal Chemistry

Chemoprevention StrategyMolecular BiologyClinical CandidatePharmacotherapyChemical Biology +17

Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases

Adrian L. Smith, Noel D. D’Angelo, Yunxin Bo, +29

Journal of Medicinal Chemistry

Effect of microwave heating on Ullmann-type heterocycle-aryl ether synthesis using chloro-heterocycles

Noel D. D’Angelo, Joseph J. Peterson, Shon K. Booker, +5

Tetrahedron Letters

Chemical EngineeringCross-coupling ReactionEngineeringHeterocyclicOrganic Chemistry +5

Function-Oriented Synthesis:  Studies Aimed at the Synthesis and Mode of Action of 1α-Alkyldaphnane Analogues

Paul A. Wender, Noel D. D’Angelo, Vassil I. Elitzin, +7

Organic Letters