Concepedia

Joseph Ligutti

JL

22

Publications

887

Citations

18

H-Index

2004

Active since

Affiliations

Amgen (United States)(Current)

Atheris Laboratories (Switzerland)

Joseph Ligutti is an author at Amgen (United States) specializing in medicine, drug discovery, and natural sciences.

Top concepts

Publications per year

2004–2020

22

Publications

22

Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the Na<sub>V</sub>1.7 Sodium Channel

Justin K. Murray, Joseph Ligutti, Dong Liu et al. · Journal of Medicinal Chemistry · 2015 · 116 citations · Full text

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Automated Tight Seal Electrophysiology for Assessing the Potential hERG Liability of Pharmaceutical Compounds

Huimin Tao, David Santa Ana, António Guia et al. · Assay and Drug Development Technologies · 2004 · 80 citations

Sulfonamides as Selective Na<sub>V</sub>1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity

Russell F. Graceffa, Alessandro A. Boezio, Jessica Able et al. · Journal of Medicinal Chemistry · 2017 · 66 citations · Full text

Identification of a Potent, State-Dependent Inhibitor of Nav1.7 with Oral Efficacy in the Formalin Model of Persistent Pain

Howard Bregman, Loren Berry, John L. Buchanan et al. · Journal of Medicinal Chemistry · 2011 · 54 citations · Full text

Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7

Thomas Kornecook, Ruoyuan Yin, Stephen M. Altmann et al. · Journal of Pharmacology and Experimental Therapeutics · 2017 · 52 citations

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