Design and Synthesis of Conformationally Constrained Glucagon-Like Peptide-1 Derivatives with Increased Plasma Stability and Prolonged in Vivo Activity

Les P. Miranda, Katherine A. Winters, Colin V. Gegg, +12

Journal of Medicinal Chemistry

EngineeringPeptide EngineeringGlycobiologyMolecular BiologyChemical Biology +16

Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the Na_V1.7 Inhibitory Peptide GpTx-1

Justin K. Murray, Jason Long, Anruo Zou, +7

Journal of Medicinal Chemistry

Drug TargetMolecular BiologyPeptide ScienceMolecular PharmacologySingle Residue Substitutions +18

Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V

Bryan D. Moyer, Justin K. Murray, Joseph Ligutti, +15

PLoS ONE

Pharmacological CharacterizationMolecular BiologyMolecular PainPharmacotherapyMolecular Pharmacology +15

Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction

Sandra L. Ross, Kaustav Biswas, James B. Rottman, +5

Frontiers in Pharmacology

Small Molecule AntagonistsIron MetabolismControl FluxesIron DeficiencyRedox Biology +18

Discovery of Tarantula Venom-Derived Na_V1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis

Bin Wu, Justin K. Murray, Kristin L. Andrews, +16

Journal of Medicinal Chemistry

Identification and Optimization of a Minor Allele-Specific siRNA to Prevent PNPLA3 I148M-Driven Nonalcoholic Fatty Liver Disease

Justin K. Murray, Jason Long, Lei Liu, +15

Nucleic Acid Therapeutics

Purification of N-acetylgalactosamine-modified-oligonucleotides using orthogonal anion-exchange and mixed-mode chromatography approaches

Artaches A. Kazarian, Wesley W. Barnhart, Jason Long, +3

Journal of Chromatography A

Orthogonal Anion-exchangeEngineeringBiochemistryBioanalysisGlycobiology +8

Engineering Na_V1.7 Inhibitory JzTx-V Peptides with a Potency and Basicity Profile Suitable for Antibody Conjugation To Enhance Pharmacokinetics

Justin K. Murray, Bin Wu, Christopher M. Tegley, +29

ACS Chemical Biology

Purification of guanine-quadruplex using monolithic stationary phase under ion-exchange conditions

Artaches A. Kazarian, Wesley W. Barnhart, Iain D. G. Campuzano, +6

Journal of Chromatography A

Chemical EngineeringEngineeringMonolithic Stationary PhaseChemistryPurification Method +1

Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model

Essa Hu, Fang‐Tsao Hong, Jennifer Aral, +14

Journal of Medicinal Chemistry