Russell F. Graceffa

Design and SAR of Novel Potassium Channel Openers Targeted for Urge Urinary Incontinence. 1. <i>N</i>-Cyanoguanidine Bioisosteres Possessing in Vivo Bladder Selectivity

John A. Butera, Madelene Antane, Schuyler Antane et al. · Journal of Medicinal Chemistry · 2000 · 79 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Novel 2,3-Dihydro-1,4-Benzoxazines as Potent and Orally Bioavailable Inhibitors of Tumor-Driven Angiogenesis

Daniel S. La, Julie Belzile, James Bready et al. · Journal of Medicinal Chemistry · 2008 · 73 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Naphthamides as Novel and Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Design, Synthesis, and Evaluation

Jean-Christophe Harmange, Matthew M. Weiss, Julie Germain et al. · Journal of Medicinal Chemistry · 2008 · 70 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Sulfonamides as Selective Na_V1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity

Russell F. Graceffa, Alessandro A. Boezio, Jessica Able et al. · Journal of Medicinal Chemistry · 2017 · 69 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Structure- and Property-Based Design of Aminooxazoline Xanthenes as Selective, Orally Efficacious, and CNS Penetrable BACE Inhibitors for the Treatment of Alzheimer’s Disease

Hongbing Huang, Daniel S. La, Alan C. Cheng et al. · Journal of Medicinal Chemistry · 2012 · 68 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17