Alan C. Cheng

Structure-based maximal affinity model predicts small-molecule druggability

Alan C. Cheng, Ryan G. Coleman, Kathleen T Smyth et al. · Nature Biotechnology · 2007 · 684 citations

Drug Target, Medicine, Small-molecule Druggability +6

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies

Sean Caenepeel, Sean P. Brown, Brian Belmontes et al. · Cancer Discovery · 2018 · 408 citations · Full text

Improvement in ADMET Prediction with Multitask Deep Featurization

Evan N. Feinberg, Elizabeth Joshi, Vijay S. Pande et al. · Journal of Medicinal Chemistry · 2020 · 188 citations

Engineering, Machine Learning, Deep Featurization +20

Recognition of Nucleic Acid Bases and Base-pairs by Hydrogen Bonding to Amino Acid Side-chains

Alan C. Cheng, William W. Chen, Cynthia N. Fuhrmann et al. · Journal of Molecular Biology · 2003 · 141 citations

Nucleic Acid Chemistry, Nucleic Acid Bases, Biochemistry +11

Structure of the Catalytic Domain of Human Polo-like Kinase 1^,

Michael Kothe, Darcy Kohls, Simon Low et al. · Biochemistry · 2007 · 123 citations

Catalytic Domain, Molecular Biology, Chemical Biology +19