Small-molecule WNK inhibition regulates cardiovascular and renal function

Ken Yamada, Hyi-Man Park, Dean F. Rigel, +58

Nature Chemical Biology

Molecular PhysiologyKidney ResearchMedicinePhysiologyPharmacology +6

Research Article: Selectivity‐determining Residues in Plk1

Michael Kothe, Darcy Kohls, Simon Low, +5

Chemical Biology & Drug Design

Bi 2536Residue (Chemistry)Signaling PathwayMedicineReceptor Tyrosine Kinase +12

Structure of the Catalytic Domain of Human Polo-like Kinase 1^,

Michael Kothe, Darcy Kohls, Simon Low, +12

Biochemistry

Catalytic DomainMolecular BiologyChemical BiologyTumor BiologySignaling Pathway +17

Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity

Xiaoling Xie, Daniel Baird, Kimberly Elizabeth Bowen, +20

Structure

Molecular PharmacologyBiochemistryNatural SciencesMedicineIdh1 Mutant +5

Structural Determinants for Inhibitor Specificity and Selectivity in PDE2A Using the Wheat Germ in Vitro Translation System

André Iffland, Darcy Kohls, Simon Low, +7

Biochemistry

Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2

Jeffrey W. Corbett, Kevin D. Freeman‐Cook, Richard L. Elliott, +21

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryNatural SciencesMedicineDrug Development +7

Identification of Allosteric PIF‐Pocket Ligands for PDK1 using NMR‐Based Fragment Screening and ¹H‐¹⁵N TROSY Experiments

Brian J. Stockman, Michael Kothe, Darcy Kohls, +9

Chemical Biology & Drug Design

The crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase: implications for substrate channeling in a bifunctional enzyme

Darcy Kohls, Traian Sulea, Enrico O. Purisima, +2

Structure

Crystal StructureBiochemistryNatural SciencesEnzyme CatalysisMolecular Biology +5

Discovery and Characterization of Allosteric WNK Kinase Inhibitors

Ken Yamada, Ji-Hu Zhang, Xiaoling Xie, +23

ACS Chemical Biology

Molecular DockingMedicinal ChemistryDrug TargetBiochemistryRubidium Uptake +10

Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models

Ken Yamada, Julian Levell, Taeyong Yoon, +22

Journal of Medicinal Chemistry

Crystal StructureHypertensionKinase InhibitorsPharmacotherapyRodent Hypertension Models +15