Howard Bregman

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

Monika Bambousková, Laurent Gorvel, Vicky Lampropoulou et al. · Nature · 2018 · 695 citations · Full text

Inflammation, Cytokine, Inflammatory Disease +12

Ruthenium Half‐Sandwich Complexes Bound to Protein Kinase Pim‐1

J.E. Debreczeni, Alex N. Bullock, G. Ekin Atilla et al. · Angewandte Chemie International Edition · 2006 · 232 citations

An Organometallic Protein Kinase Inhibitor Pharmacologically Activates p53 and Induces Apoptosis in Human Melanoma Cells

Keiran S.M. Smalley, Rooha Contractor, Nikolas K. Haass et al. · Cancer Research · 2007 · 230 citations

Rapid Access to Unexplored Chemical Space by Ligand Scanning around a Ruthenium Center:  Discovery of Potent and Selective Protein Kinase Inhibitors

Howard Bregman, Patrick J. Carroll, Eric Meggers · Journal of the American Chemical Society · 2005 · 146 citations

Drug Target, Rapid Access, Molecular Biology +19

Exploring Chemical Space with Organometallics: Ruthenium Complexes as Protein Kinase Inhibitors

Eric Meggers, G. Ekin Atilla‐Gokcumen, Howard Bregman et al. · Synlett · 2007 · 142 citations

Organic Ligands, Medicinal Chemistry, Biochemistry +13