Loren Berry

Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase

Brian K. Albrecht, Jean-Christophe Harmange, David Bauer et al. · Journal of Medicinal Chemistry · 2008 · 138 citations · Full text

Combinatorial Chemistry, Chemoprevention Strategy, Selective Inhibitors +22

Esterase Activities in the Blood, Liver and Intestine of Several Preclinical Species and Humans

Loren Berry, Lance Wollenberg, Zhiyang Zhao · Drug Metabolism Letters · 2009 · 111 citations

Medicinal Chemistry, Biosynthesis, Tissue Differences +14

An Examination of IC50 and IC50-Shift Experiments in Assessing Time-Dependent Inhibition of CYP3A4, CYP2D6 and CYP2C9 in Human Liver Microsomes

Loren Berry, Zhiyang Zhao · Drug Metabolism Letters · 2008 · 107 citations

Sex Differences in Sensitivity to the Depressive-like Effects of the Kappa Opioid Receptor Agonist U-50488 in Rats

Shayla Russell, Anna B. Rachlin, Karen L. Smith et al. · Biological Psychiatry · 2013 · 107 citations · Full text

Psychiatry, Behavioral Neuroscience, Addiction +10

Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-<i>N</i>-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1<i>H</i>-pyrazole-4-carboxamide (AMG 458)

Longbin Liu, Aaron Siegmund, Ning Xi et al. · Journal of Medicinal Chemistry · 2008 · 94 citations · Full text

Pharmaceutical Science, Metabolic Hot Spot, Chemoprevention Strategy +21