Identification of the Clinical Development Candidate <b>MRTX849</b>, a Covalent KRAS^G12C Inhibitor for the Treatment of Cancer

Jay B. Fell, John P. Fischer, Brian R. Baer, +31

Journal of Medicinal Chemistry

A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion–Positive Solid Tumors

Alexander Drilon, Ramamoorthy Nagasubramanian, James F. Blake, +31

Cancer Discovery

Esterase Activities in the Blood, Liver and Intestine of Several Preclinical Species and Humans

Loren Berry, Lance Wollenberg, Zhiyang Zhao

Drug Metabolism Letters

Medicinal ChemistryBiosynthesisTissue DifferencesPharmacological StudyBiochemistry +12

Electrocatalytic Drug Metabolism by CYP2C9 Bonded to A Self-Assembled Monolayer-Modified Electrode

Mingli Yang, Jarod L. Kabulski, Lance Wollenberg, +6

Drug Metabolism and Disposition

Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia

Lohith Bachegowda, Kerry Morrone, Shannon L. Winski, +32

Cancer Research

Novel Dual InhibitorMixed-phenotype Acute LeukemiaImmunologyPharmacotherapyMyeloid Neoplasia +15

A Phase Ib/II Study of the BRAF Inhibitor Encorafenib Plus the MEK Inhibitor Binimetinib in Patients with <i>BRAFV600E/K</i> -mutant Solid Tumors

Ryan J. Sullivan, Jeffrey S. Weber, Sapna P. Patel, +10

Clinical Cancer Research

Self-Organized Honeycomb Structures of Mn₁₂ Single-Molecule Magnets

Hang Sun, Wen Li, Lance Wollenberg, +4

The Journal of Physical Chemistry B

A phase Ib/II dose-escalation study evaluating triple combination therapy with a BRAF (encorafenib), MEK (binimetinib), and CDK 4/6 (ribociclib) inhibitor in patients (Pts) with <i>BRAF V600</i>-mutant solid tumors and melanoma.

Paolo A. Ascierto, Oliver Bechter, Pascal Wolter, +12

Journal of Clinical Oncology

ImmunologyPathologyImmunotherapeuticsConfirmed Braf V600Oncology +14

The Use of Immobilized Cytochrome P4502C9 in PMMA-Based Plug Flow Bioreactors for the Production of Drug Metabolites

Lance Wollenberg, Jarod L. Kabulski, Matthew J. Powell, +4

Applied Biochemistry and Biotechnology

BiomanufacturingEngineeringBiochemistryMedicineBioanalysis +11

Measurement of Electron Transfer through Cytochrome P450 Protein on Nanopillars and the Effect of Bound Substrates

John E. Jett, David Lederman, Lance Wollenberg, +5

Journal of the American Chemical Society

EngineeringBioelectrochemistryCytochrome P450 ProteinChemistryRedox Biology +16