Publication | Closed Access
Esterase Activities in the Blood, Liver and Intestine of Several Preclinical Species and Humans
111
Citations
0
References
2009
Year
Medicinal ChemistryBiosynthesisTissue DifferencesPharmacological StudyBiochemistryNatural SciencesEster CompoundsPhysiologyMedicineDog MonkeyExperimental PharmacologySeveral Preclinical SpeciesDigestive TractIngestionMetabolismPharmacologyEsterase Activities
Species and tissue differences in the activity of three major classes of esterases, carboxylesterase (CE), butyrylcholinesterase (BChE) and paraoxonase (PON), were studied. Substantial species differences in activity of these esterases were observed between the mouse, rat, dog monkey and human. Such species differences must be considered when using these preclinical species to optimize the pharmacokinetic properties of ester compounds intended for human use.