David J. Malwitz

Biochemical, Cellular, and <i>In vivo</i> Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin

Ker Yu, Lourdes Toral‐Barza, Celine Shi et al. · Cancer Research · 2009 · 326 citations

Chemoprevention Strategy, Cellular Pharmacology, Selective Inhibitors +22

Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability

Paul E. Harrington, Kaustav Biswas, David J. Malwitz et al. · ACS Medicinal Chemistry Letters · 2014 · 103 citations · Full text

Cellular Viability, Kinase Site, Protein Response +20

ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines

Arie Zask, Jeroen C. Verheijen, Kevin J. Curran et al. · Journal of Medicinal Chemistry · 2009 · 98 citations · Full text

Chemical Biology, Pharmaceutical Chemistry, Tumor Biology +19

Discovery of 4-Morpholino-6-aryl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidines as Highly Potent and Selective ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin (mTOR): Optimization of the 6-Aryl Substituent

Jeroen C. Verheijen, David J. Richard, Kevin J. Curran et al. · Journal of Medicinal Chemistry · 2009 · 52 citations · Full text

Drug Target, Pharmacotherapy, Pharmaceutical Chemistry +20

Discovery of Potent and Selective Inhibitors of the Mammalian Target of Rapamycin (mTOR) Kinase

Paweł Nowak, Derek C. Cole, Natasja Brooijmans et al. · Journal of Medicinal Chemistry · 2009 · 51 citations · Full text

Drug Target, Selective Inhibitors, Mtor Ic +18