Kate S. Ashton

Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors

Brian A. Lanman, Jennifer R. Allen, John G. Allen et al. · Journal of Medicinal Chemistry · 2019 · 722 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +16

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

David J. Lloyd, David J. St. Jean, Robert J. Kurzeja et al. · Nature · 2013 · 98 citations

Life Sciences, Biochemistry, Pharmacology +14

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 3. Structure–Activity Relationships within the Aryl Carbinol Region of the <i>N</i>-Arylsulfonamido-<i>N</i>′-arylpiperazine Series

Nobuko Nishimura, Mark H. Norman, Longbin Liu et al. · Journal of Medicinal Chemistry · 2014 · 54 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +11

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (n_N → σ*_S–X) Interaction for Conformational Constraint

Lewis D. Pennington, Michael D. Bartberger, Michael D. Croghan et al. · Journal of Medicinal Chemistry · 2015 · 41 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept

Kate S. Ashton, Kristin L. Andrews, Marion C. Bryan et al. · Journal of Medicinal Chemistry · 2014 · 33 citations · Full text

Life Sciences, Biochemistry, Pharmacology +9